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S01 - Developmental biology

Download 2020-2021 planning

Biology Master, ENS
Year : 1 (M1)
Semester : 1 (S1)

Course code :

BIO-M1-S01-S1

Course name :

Developmental biology

Coordinator :

Iris Salecker

ECTS :

6

Keywords :

Morphogenesis, stem cells, cell differentiation, apoptosis, cell migration, patterning, regeneration, organogenesis, gametogenesis, organoids, evo-devo, model and non-model organisms

Prerequisites for the course :

There are no specific requirements to attend this module. However, participants should bring plenty of curiosity and an inquisitive mind ! Some background in cell, molecular and developmental biology, as well as genetics will be useful.

Course description :

A single cell, the fertilized egg with a single genome will give rise to hundreds of very different specialized cell subtypes, which organize themselves, adopt specific forms within organs of the right size during development, to finally give birth to an impressively complex adult organism. How this is achieved remains a fascinating question. Understanding development also lies at the heart of understanding diseases. This module has the aim to introduce students to advanced concepts of developmental biology research. Leading scientists, in a collaboration of French and UK laboratories, will provide introductions into the background of their respective research areas and share insights about their own exciting research to give participants a feel for the discipline as it is happening at the bench. They will cover the fundamental mechanisms orchestrating morphogenesis, patterning, stem cell biology, cell fate specification, cell migration, apoptosis, organ formation, regeneration and evo/devo. The course will explore the use of different model and non-model organisms and the various techniques, including Crispr/Cas9 genetic manipulations, that make it possible to find answers through the synthesis of knowledge obtained from imaging, genetics and genomics combined with molecular biology. The course will also convey the notion that Developmental biology research is a very active discipline that continues to transform itself as advances in technology are opening unprecedented doors for future studies.

Assessment / evaluation :

Details will depend on the number of students attending the course. Grades will be based on article presentations and discussions (« journal clubs ») of students either individually or in teams, course participation, as well as a written exam about the topics covered in the course.

Course material (hand-outs, online presentation available, …) :

PDF versions of presentations and material for course work will be provided and accessible online.

Suggested readings in relationship with the module content :

• Primary literature and review articles related to presented topics
• Some chapters in relevant textbooks (Michael Barresi and Scott Gilbert : Developmental Biology ; Lewis Wolpert, Cheryll Tickle, Alfonso Martinez Arias : Principles of Development)