Associated laboratories : INSERM
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM
INSERM Paris 7 - Research
• Quantitative Evolutionary Microbiology
Infectious diseases remain one of the greatest challenges for our societies.
The last decades have revealed that the success of microbes comes from their ability to adapt to both immune and pharmaceutical selective pressures.
• The aim of our team is to try to better characterize the evolvability of bacterial species with an integrated approach. We use mathematics and population genetics models of adaptation, experimental evolution as well as epidemiological sampling coupled to whole genome sequencing, molecular genetics and high throughput phenotyping to study the different adaptive facets of the model organism Escherichia coli. E. coli, is not only the best characterized microorganism, it is also a versatile pathogen that kills a million person a year and is becoming a major health public concern with its rising resistance to antibiotics. We aim at combining our different approaches in an integrated framework to capture the evolvability of that bacteria, in the lab in vitro and in vivo (in the mice gut) as well as its natural environment through extensive sampling of the microbiota of well characterized individuals.
• Keywords : Microbial evolution, Experimental evolution, Genomics, Population genetics, Modelling, Infectious Diseases
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Contact : Olivier Tenaillon