Associated laboratories : Institut de Biologie Physico-Chimique - IBPC
INSTITUT DE BIOLOGIE PHYSICO CHIMIQUE : IBPC
• Telomere Biology
The linear chromosomes of eukaryotes end with telomeres. Because of the inability of semi‐conservative DNA replication machinery to fully duplicate DNA ends, telomeres display a singular dynamic structure, providing both a mechanism to ensure the integrity of the genome and a mode of control of cell division in eukaryotes. Since telomeres physiologically shrink at each cell division, they are considered as molecular clocks for the counting of number of generations before replicative senescence. Our goal is to understand the so‐called DNA end replication problem and its consequences at the cellular level using Saccharomyces cerevisiae as an experimental model.
Projects include :
– the dissection of the structure of single telomeres using the DNA combing technology associated with super-resolution microscopy.
– the understanding of the mechanisms that lead to the establishment of replicative senescence using sophisticated cellular settings, molecular biology and genomic approaches.
– the study of the link between the structure of telomeres and cell proliferation capacity by the analysis of growth of single cells using a novel microfluidic device.
Lab website
Contact : Teresa Texeira